Table 1.

Pathways represented among the 77 genes associated with AD and differentially expressed upon activation with Hp(2-20).

Pathways	Genes
Alzheimer disease-amyloid secretase pathway (P00003)	PRKCI, MAPK8, MAPK13, ADAM9, MAPK3, ADAM17, PRKCQ, PKN2, APP, PSEN1, PSEN2, PRKACA
Alzheimer disease-presenilin pathway (P00004)	RBPJ, ACTL8, APBB2, FZD5, WNT10B, LRP6, ADAM17, NECTIN1, TCF7L2, PSEN1, PSEN2, NOTCH1, CTNNB1, CTNNA1, APP
Angiogenesis (P00005)	PRKCI, FRS2, RBPJ, RASA1, FZD5, MAPK8, PIK3CB, NRAS, WNT10B, SOS2, PRR5, PLA2G4A, MAP3K1, MAPK3, MAP2K4, SRC, PTPN, PLD2, PLCG2, RHOC, BRAF, TCF7L2, PRKCQ, PRKACA, NOTCH1, CTNNB1
VEGF signaling pathway (P00056)	PRKCI, PIK3CB, NRAS, PRR5, PLA2G4A, MAPK3, PLCG2, BRAF, PRKCQ, PRKACA
EGF receptor signaling pathway (P00018)	PPP4C, PRKCI, PPP2CB, RASA1, RHOG, YWHAH, MAPK8, PIK3CB, NRAS, GAB1, SOS2, SPRY4, NEK1, MAPK13, MAP3K1, PPP6, MAPK3, MAP2K4, RASA2, PLCG2, BRAF, PRKCQ, CBLB, ERBB3, PRKACA
Wnt signaling pathway (P00057)	LRP6, PRKCI, PPP2CB, PRKACA, PRKCQ, ARRB1, ACTL8, GNAQ, FZD5, TCF7L2, WNT10B, CTNNB1, CTNNA1
Inflammation mediated by chemokine and cytokine signaling pathway (P00031)	ARRB1, PRKACA, ACTL8, RHOG, GNAQ, REL, PIK3CB, NRAS, IFNAR1, NFKB1, ARPC1B, PDPK1, IKBKE, PLA2G4A, ROCK1, PRKX, GRK6, MAPK3, ARPC4, PLCG2, RELA, SOCS6, RHOC, BRAF, PTEN, JUNB, FPR1, FPR2, FPR3, ANXA1

*The FDR value of listed genes was <0.05.