Table 2.

Genes of Alzheimer disease-amyloid secretase and Alzheimer disease-presenilin pathways catalogued in the Panther database and differently expressed upon activation with Hp(2-20).

Pathways name	Gene ID	Gene name	FDR	log2FC
Alzheimer disease-amyloid secretase pathway	PRKCI	Protein kinase C iota type	3.11E-02	−0.11
	MAPK8	Mitogen-activated protein kinase 8	4.24E-02	−0.15
	MAPK13	Mitogen-activated protein kinase 13	3.51E-02	0.10
	ADAM9	Disintegrin and metalloproteinase domain-containing protein 9	2.51E-02	−0.08
	MAPK3	Mitogen-activated protein kinase 3	1.52E-02	0.23
	ADAM17	Disintegrin and metalloproteinase domain-containing protein 17	2.55E-02	−0.26
	PRKCQ	Protein kinase C theta type	3.03E-02	−0.22
	PKN2	Serine/threonine-protein kinase N2	1.73E-02	−0.26
	APP	Amyloid Beta Precursor Protein	2.94E-02	0.04
	PSEN1	Presenilin 1	2.77E-02	0.35
	PSEN2	Presenilin 2	1.83E-02	0.49
	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	3.50E-02	0.14
Alzheimer disease-presenilin pathway	RBPJ	Recombining binding protein suppressor of hairless	2.48E-02	−0.21
	ACTL8	Actin-like protein 8	3.14E-02	−0.48
	APBB2	Amyloid beta A4 precursor protein-binding family B member 2	2.99E-02	−0.18
	FZD5	Frizzled-5	4.99E-02	0.10
	WNT10B	Protein Wnt-10b	2.72E-02	0.30
	LRP6	Low-density lipoprotein receptor-related protein 6	2.48E-02	−0.22
	ADAM17	Disintegrin and metalloproteinase domain-containing protein 17	2.55E-02	−0.26
	NECTIN1	Nectin-1	3.86E-02	0.10
	PSEN1	Presenilin 1	2.77E-02	0.35
	PSEN2	Presenilin 2	1.83E-02	0.49
	NOTCH1	Notch 1	1.21E-002	0.36
	CTNNB1	Catenin Beta 1	8.98E-03	−0.18
	CTNNA1	Catenin Alpha 1	1.87E-02	0.30
	APP	Amyloid Beta Precursor Protein	2.94E-02	0.04
	TCF7L2	Transcription factor 7-like 2	3.14E-02	−0.18