Table 3.
Pathways and functions activated by unique and total Hp(2-20) genes detected by IPA software.
| Hp(2-20) peptide | |||||
|---|---|---|---|---|---|
| Total | Unique | ||||
| Top Canonical Pathways | Top Canonical Pathways | ||||
| Name | p-value | Overlap | Name | p-value | Overlap |
| EIF2 Signaling | 5.05E-19 | 52.0% 115/221 | Insulin Receptor Signaling | 1.34E-06 | 22.0% 31/141 |
| Regulation of eIF4 and p70S6K Signaling | 1.22E-14 | 52.9% 83/157 | Tight Junction Signaling | 2.70E2.70E-06 | 20.4% 34/167 |
| mTOR Signaling | 6.16E-14 | 48.7% 97/199 | Amyloid Processing | 4.18E-06 | 31.40% 16/51 |
| Protein Ubiquitination Pathway | 2.82E-13 | 45.1% 115/255 | IGF-1 Signaling | 1.20E-05 | 22.6% 24/106 |
| Glucocorticoid Receptor Signaling | 3.35E-12 | 42.9% 123/287 | RAR Activation | 1.96E-05 | 18.4% 35/190 |
| Top Diseases and Bio Functions | Top Diseases and Bio Functions | ||||
| Diseases and Disorders | Diseases and Disorders | ||||
| Name | p-value | #Molecules | Name | p-value | #Molecules |
| Cancer | 1.50E-06-5.74E-101 | 4703 | Cancer | 7.67E-03-4.82E-28 | 1683 |
| Organismal Injury and Abnormalities | 1.67E-06-5.74E-101 | 4746 | Organismal Injury and Abnormalities | 7.67E-03-4.82E-28 | 1695 |
| Gastrointestinal Disease | 1.30E-06-1.75E-69 | 3977 | Gastrointestinal Disease | 7.67E-03-8.77E-17 | 1402 |
| Infectious Diseases | 1.93E-08-7.62E-31 | 796 | Infectious Diseases | 7.67E-03-1.08E-07 | 273 |
| Developmental Disorder | 8.60E-07-5.97E-23 | 644 | Hematological Disease | 7.67E-03-5.04E-05 | 151 |