Table 5.
Profiles of 65 AD genes catalogued in the AlzBase database.
| Gene | AlzBase | This study | Gene | AlzBase | This study | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sum | Up | Dn | Pe | FDR | Log2FC | Sum | Up | Dn | Pe | FDR | Log2FC | ||
| ADAM17 | 4 | 3 | 1 | 0 | 2.55E-02 | −0.26 | PDPK1 | 6 | 4 | 2 | 0 | 4.15E-02 | −0.13 |
| ADAM9 | 2 | 0 | 1 | 1 | 2.51E-02 | −0.08 | PIAS1 | 3 | 2 | 1 | 0 | 3.16E-02 | −0.18 |
| ANXA1 | 9 | 9 | 0 | 0 | 3.21E-02 | 0.13 | PIK3CB | 3 | 3 | 0 | 0 | 3.24E-02 | −0.12 |
| APBB2 | 3 | 0 | 3 | 0 | 2.99E-02 | −0.18 | PKN2 | 9 | 7 | 1 | 1 | 1.73E-02 | −0.26 |
| APOE | 4 | 4 | 0 | 0 | 2.56E-02 | 0.78 | PLA2G4A | 2 | 2 | 0 | 0 | 3.12E-02 | −0.17 |
| APP | 7 | 0 | 6 | 1 | 2.94E-02 | 0.04 | PLCG2 | 4 | 4 | 0 | 0 | 4.27E-02 | −0.2 |
| ARPC1B | 6 | 6 | 0 | 0 | 1.85E-02 | 0.18 | PLD2 | 5 | 2 | 3 | 0 | 2.83E-02 | 0.15 |
| ARPC4 | 3 | 0 | 3 | 0 | 2.86E-02 | 0.11 | PPP2CB | 4 | 0 | 4 | 0 | 3.79E-02 | −0.08 |
| ARRB1 | 9 | 5 | 3 | 1 | 2.29E-02 | 0.33 | PRKACA | 3 | 0 | 3 | 0 | 3.50E-02 | 0.14 |
| BRAF | 1 | 0 | 1 | 0 | 2.44E-02 | −0.34 | PRKCI | 4 | 4 | 0 | 0 | 3.11E-02 | −0.11 |
| CBLB | 8 | 6 | 1 | 1 | 3.19E-02 | −0.29 | PRKCQ | 3 | 0 | 3 | 0 | 3.03E-02 | −0.22 |
| CTNNA1 | 6 | 4 | 2 | 0 | 1.87E-02 | 0.3 | PRKX | 10 | 9 | 0 | 1 | 3.11E-02 | −0.2 |
| CTNNB1 | 1 | 0 | 1 | 0 | 8.98E-03 | −0.18 | PRR5 | 2 | 1 | 1 | 0 | 2.88E-02 | 0.27 |
| EIF4E | 5 | 0 | 5 | 0 | 2.05E-02 | −0.24 | PSEN1 | 2 | 1 | 1 | 0 | 2.77E-02 | 0.35 |
| ERBB3 | 7 | 6 | 1 | 0 | 4.24E-02 | −0.08 | PSEN2 | 6 | 0 | 4 | 2 | 1.83E-02 | 0.49 |
| FPR1 | 8 | 6 | 2 | 0 | 3.06E-02 | 0.12 | PTEN | 1 | 1 | 0 | 0 | 3.26E-02 | −0.11 |
| FPR2 | 4 | 2 | 2 | 0 | 2.93E-02 | 0.59 | RASA1 | 4 | 0 | 4 | 0 | 2.43E-02 | −0.19 |
| FZD5 | 3 | 3 | 0 | 0 | 4.99E-02 | 0.1 | RASA2 | 5 | 1 | 4 | 0 | 3.11E-02 | −0.28 |
| GAB1 | 8 | 5 | 3 | 0 | 2.48E-02 | −0.28 | RBPJ | 1 | 0 | 1 | 0 | 2.48E-02 | −0.21 |
| GNAQ | 4 | 4 | 0 | 0 | 2.53E-02 | −0.21 | REL | 2 | 1 | 1 | 0 | 2.42E-02 | −0.54 |
| JUNB | 7 | 7 | 0 | 0 | 1.95E-02 | 0.34 | RELA | 8 | 7 | 0 | 1 | 4.35E-02 | −0.09 |
| LRP11 | 5 | 3 | 2 | 0 | 4.31E-02 | 0.11 | RHOC | 6 | 6 | 0 | 0 | 2.82E-02 | 0.21 |
| LRP6 | 4 | 2 | 2 | 0 | 2.48E-02 | −0.22 | RHOG | 7 | 7 | 0 | 0 | 4.91E-02 | 0.11 |
| MAP2K4 | 11 | 1 | 10 | 0 | 2.48E-02 | −0.26 | ROCK1 | 5 | 5 | 0 | 0 | 3.11E-02 | −0.14 |
| MAP3K1 | 3 | 3 | 0 | 0 | 2.17E-02 | 0.23 | RPS6KB2 | 2 | 2 | 0 | 0 | 2.84E-02 | 0.15 |
| MAPK13 | 3 | 2 | 1 | 0 | 3.51E-02 | 0.1 | SOCS6 | 2 | 0 | 2 | 0 | 4.28E-02 | −0.16 |
| MAPK3 | 2 | 0 | 2 | 0 | 1.52E-02 | 0.23 | SOS2 | 3 | 3 | 0 | 0 | 2.41E-02 | −0.29 |
| MAPK8 | 9 | 2 | 6 | 1 | 4.24E-02 | −0.15 | SPRY4 | 6 | 1 | 5 | 0 | 2.85E-02 | 0.32 |
| MKNK2 | 10 | 10 | 0 | 0 | 3.03E-02 | 0.13 | SRC | 3 | 2 | 1 | 0 | 2.39E-02 | −0.18 |
| NEK1 | 5 | 2 | 3 | 0 | 2.73E-02 | −0.3 | TCF7L2 | 3 | 3 | 0 | 0 | 3.14E-02 | −0.18 |
| NFKB1 | 9 | 8 | 0 | 1 | 2.35E-02 | −0.15 | WNT10B | 1 | 1 | 0 | 0 | 2.72E-02 | 0.3 |
| NOTCH1 | 14 | 14 | 0 | 0 | 1.21E-02 | 0.36 | YWHAH | 13 | 1 | 12 | 0 | 3.52E-02 | 0.08 |
| NRAS | 3 | 0 | 3 | 0 | 2.44E-02 | −0.15 | |||||||
Sum: Total number of differential expression from all transcriptome studies of Alzheimer’s disease (AD). Up: Total number of up regulation from all transcriptome studies of AD. Dn: Total number of down regulation from all transcriptome studies of AD. Pe: Total number of dys-regulation with unknown direction from all transcriptome studies of AD.