FIGURE 1.
(A) Native curcumin in DMSO. (B) 1st phase curcumin in DMSO with water. (C) 2nd phase curcumin in DMSO with water. (D) Native curcumin in acetone. (E) 1st phase curcumin in acetone with water. (F) 2nd phase curcumin in acetone with water. (G) Naïve curcumin suspended in water. The aqueous insolubility of the native curcumin can be perceived as heterogeneous yellow colored aggregations present at the top of aqueous phase and heterogeneity of suspension seen throughout (G). Curcumin upon dissolution in polar aprotic DMSO and non-polar acetone appears as dark and light mustard yellow solution, respectively (A-G). Phase 1 and 2 of wet milling utilizing DMSO (B,C) and acetone is also shown (E,F).