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. 2017 Aug 10;7:7797. doi: 10.1038/s41598-017-07513-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MiR-132 regulates RAS signalling pathway. (A) The top10 gene ontology biological process terms for the genes down-regulated by miR-132 in fibroblasts. P-values were determined by the Fisher’s exact test. (B) GSEA evaluated enrichment for the genes related to the RAS signalling within the microarray data. (C) The genes related to the RAS signalling were regulated by miR-132 in fibroblasts. Heat map illustrates levels of significantly changed genes (fold change ≥ 1.2, P < 0.05). Colour intensity is scaled within each row so that the highest expression value corresponds to bright yellow and the lowest to bright blue. (D) RASA1 was detected by qRT-PCR in HDFs transfected with 20 nM miR-132 mimics or control oligos (n = 3). The data are presented as mean ± s.d. ****P < 0.0001 by Student’s t test.