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. 2017 Aug 10;7:7748. doi: 10.1038/s41598-017-07570-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Accumulation of ceramide in cortex of rtTA-Tat mice. Concentrations of (a) dihydroceramides, (b) ceramides, (c) monohexosylceramides, and (d) dihexosylceramides, were determined in cortex of mice with the indicated genotypes. Hierarchal clustering analysis is shown to the left of each class of lipid. Blue colors indicates increase and red colors indicates decrease compared to rtTA control mice. Data are expressed as mean ± SEM, n = 6–7 per group. Bold text in table indicates p < 0.05 compared to rtTA control group. ANOVA with Tukey post hoc comparisons.