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. 2017 Aug 10;7:7719. doi: 10.1038/s41598-017-08292-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Single and multiple mediation effects. Standardized regression coefficients (standard error) for the relationship between HCY and TAC as mediated by total sleep time (A) or sleep efficiency (B) in MCI. (C) Standardized regression coefficients (standard error) for the relationship between HCY and GM loss as serially mediated by total sleep time/sleep efficiency and TAC in MCI. The standardized regression coefficient (standard error) between HCY and TAC or between HCY and cerebral GM before (c) and after controlling for either sleep or sleep and TAC (c’) are also indicated. Standardized regression coefficients (standard error) for the two-path (β1*β2) and three-path (β1*β3*β5) indirect effects together with the 95% bias-corrected bootstrap confidence intervals from 10,000 bootstrap samples are indicated in the bottom part of each model. *P < 0.05; **P < 0.005; ***P < 0.001.