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. 2017 Aug 10;7:7733. doi: 10.1038/s41598-017-08284-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic presentation of the functional properties of FPC. FPC exerts its effects on the cytoskeleton and cell-cell junctions by indirectly regulating the activity of RhoA via the E3 family of ligases. FPC helps maintain balanced TGF-β signaling by regulating the targeting of SMURF1 and 2 to TGF-β receptors after ligand binding. FPC indirectly affects sodium balance by regulating the activity of NEDD4-2 in the CD and thereby affecting degradation of ENaC. These all functions are conducted through NDFIP2 in FPC positive vesicle.