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. 2017 Aug 10;7:7802. doi: 10.1038/s41598-017-08372-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mitochondrial-derived peptides HNG and SHLP2 inhibit IAPP fibrilization. (A and B) Representative ThT kinetics traces of IAPP misfolding in the presence of a) HNG or b) SHLP2. (C) End point analysis of IAPP misfolding by ThT fluorescence at 18 hours. Trend lines are shown for clarity. Concentrations of MDPs used to inhibit IAPP misfolding are given in micromolar below the figure. *p < 0.01. Error bars represent +/− 1 standard deviation from a minimum of 3 experiments.