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. 2017 Aug 10;7:7802. doi: 10.1038/s41598-017-08372-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CW-EPR spectroscopy shows MDPs prevent loss of IAPP monomer without detectable binding to free IAPP. (A–D) EPR spectral overlay of (a) IAPP33R1 alone (black) and with HNG (red), (b) IAPP33R1 alone (black) and with SHLP2 (red), (c) IAPP17R1 alone (black) and with HNG (red), (d) IAPP17R1 alone (black) and with SHLP2 (red). (E) IAPP misfolding kinetics monitored over the course of fibrilization by central line amplitude. Symbols represent the following: (□) IAPP33R1, (◊) IAPP33R1 + HNG, (∆) IAPP33R1 + SHLP2. Error bars represent +/− 1 standard deviation. p-values of MDP treated vs. untreated IAPP33R1 at 1 hr <0.05, and at 2 + hr <0.01. (F) Average central line amplitudes for MDP treated IAPP33R1 at hour 10, *p = 0.001. Error bars represent +/− 1 standard deviation from a minimum of 3 experiments.