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. 2017 Aug 10;7:7802. doi: 10.1038/s41598-017-08372-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time-resolved circular dichroism and transmission electron microscopy confirm MDPs prevent loss of IAPP monomers and prevent fibrilization. (A–C) Circular dichroism spectra of 15 μM IAPP with molar equivalents of MDPs recorded at the beginning and end of each experiment, displayed as a weighted mean residual ellipticity (MRE’). For details regarding the calculation of MRE‘ see Materials and Methods section. (D–F) Time resolved CD of experiments in (a–c). Ellipticities were recorded at 202 nm and 218 nm to follow transitions from random coil (202 nm) to β-sheet (218 nm). Traces represent an average of at least 3 experiments. (G–I) Electron micrographs taken at the end of the experiment for (G) IAPP alone, (H) IAPP treated with HNG, and (I) IAPP treated with SHLP2. Scale bars equal 200 nm.