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. 2017 Aug 10;7:7802. doi: 10.1038/s41598-017-08372-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Co-sedimentation assay shows HNG and SHLP2 bind IAPP seeds. (A) Representative dot blot from supernatant (top) and pelleted (bottom) fractions of HNG and sonicated pre-formed IAPP fibrils (HNG + IAPP), HNG alone (HNG), or sonicated pre-formed IAPP fibrils alone (IAPP), probed with α-HN AP antibody. (B) Representative dot blot from supernatant (top) and pelleted (bottom) fractions of SHLP2 and sonicated pre-formed IAPP fibrils (SHLP2 + IAPP), SHLP2 alone (SHLP2), or sonicated pre-formed IAPP fibrils alone (IAPP), probed with α-SHLP2 antibody.