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. 2017 Aug 10;7:7780. doi: 10.1038/s41598-017-07853-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EV-miRNAs secreted from human hepatocytes infected with HBV. (A) EV-miRNAs secreted from human hapetocytes with HBV-infection or Non-infection were analyzed by performing the microarray. EV-miRNAs with more than 3-fold upregulated by HBV-infection are plotted. (B) Human candidate target genes of EV-miRNAs with more than 3-fold upregulated by HBV-infection are listed. (C) Murine candidate target genes of EV-miRNAs with more than 3-fold upregulated by HBV-infection are listed. (D) The 3′ UTR of mouse, human, Canis lupus familiaris, and Macaca fascicularis IL-21 mRNA registered in GenBank are illustrated. Nucleotide numbers are shown.