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. 2017 Aug 10;7:7755. doi: 10.1038/s41598-017-08209-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Crosstalk between PTEN and PTEN ceRNAs is reciprocal. (A,B) Real-time PCR analyses of changes in transcript expression of PTEN and PTEN ceRNAs after transfection with siRNA against TNRC6B, CNOT6L and PTEN relative to the non-targeting control in DU145 (A) and PC3 (B) cells. (C) Proliferation curve of DU145 (left) and PC3 (right) transfected with siRNAs against TNRC6B and PTEN. siPTEN and siTNRC6B result in a significant increase in growth relative to the siNC control in DU145 but not in PC3 cells.