Table 3.
Cytotoxic activities of selected microbial extracts
| Extract | Strain | Location | Yeasta | Gram‐positivea | Gram‐negativea | Conc (5 μg/ml)b , c % inhibition | |||
|---|---|---|---|---|---|---|---|---|---|
| C. albicans | S. cerevisiae | S. aureus | B. subtilis | P. aeruginosa | PANC‐1 | NCI/ADR | |||
| 23MM | B. hwajinpoensis | Pensacola Bay | +++ | – | – | – | – | 0 | 10 |
| 19MM | B. vietnamensis | Pensacola Bay | +++ | – | – | – | – | 9 | 18 |
| 42M1 | B. vietnamensis | Pensacola Bay | – | – | + | ++ | – | 18 | 18 |
| 38M1 | P. balearica | Pensacola Bay | – | – | – | – | – | 8 | 20 |
| 40M1 | P. stutzeri | Pensacola Bay | – | – | ++ | ++ | – | 18 | 26 |
| 47MM | B. flexus | Pensacola Beach | – | – | – | – | – | 18 | 26 |
| 12MD1 | M. iranicum | Port St. Joe | +++ | – | – | – | – | 0 | 16 |
| DMMd | A. chordae | Port St. Joe | +++ | – | ++ | ++ | – | 32 | 20 |
| MARd | B. formosus | Port St. Joe | +++ | – | – | – | – | 4 | 16 |
| NY | – | – | +++ | +++ | ND | ND | ND | ND | ND |
| GM | – | – | ND | ND | ND | +++ | +++ | ND | ND |
| CB | – | – | ND | ND | +++ | ND | ND | ND | ND |
a
Activity is classified according to the diameter of the inhibition zone (+++ = ≥15 mm; ++ = 10–14 mm; + = ≤9 mm; – = no activity; ND = Not Done), NY = Nystatin (100 U), GM = Gentamicin (10 μg), CB = Carbenicillin (100 μg).
b
Pancreatic cancer cell line (PANC‐1) and the multidrug‐resistant ovarian cancer cell line (NCI/ADR).
c
No significant activity.
d
The sponge microbial isolates.