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. Author manuscript; available in PMC: 2017 Aug 11.
Published in final edited form as: Methods Mol Biol. 2016;1462:289–324. doi: 10.1007/978-1-4939-3816-2_17

Fig. 1.

Fig. 1

Modeling closed-head diffuse brain injury in swine. (a) Conceptual schematic of diffuse TBI in humans, which is most often caused by rapid rotational acceleration/deceleration of the head. Such inertial loading due to angular acceleration/velocity generates diffuse strain patterns in the brain. (b) Mock-up showing predicted tissue deformation during head rotational acceleration–deceleration loading of the pig brain during rapid head rotation in the coronal plane. Head rotational parameters, in particular angular acceleration, may be scaled from humans to gyrencephalic mammals based on brain mass. Figure adapted with permission from [30]