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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2017 May 19;25(15):3947–3963. doi: 10.1016/j.bmc.2017.05.032

Scheme 4.

Scheme 4

Synthesis of 2-Substituted Indole Intermediatesa

aReagents and conditions. (a) POCl3, DMF, DCE, 0 °C to rt; (b) Ph3P+CH2YX−, BuLi, THF, −78 °C or 0 °C to rt; (c) I2, AgOTf, THF, −78 °C; (d) 3-methoxyprop-1-yne, Pd(Ph3P)2Cl2, CuI, Et3N, DMF.