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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2017 May 19;25(15):3947–3963. doi: 10.1016/j.bmc.2017.05.032

Scheme 7.

Scheme 7

Synthesis of 6-(2-Aminopyridyl)benzoxazinone Analogsa

aReagents and conditions. (a) Pd(PPh3)4, LiCl, CsOH H2O, aq. dioxane, 100 °C; (b) Br (CH2)2NHCO2Me, NaH, NaH, 15-cr-5, DMF; (c) (i) bis(pinacolato)diboron, Pd(dppf)Cl2, KOAc, dioxane, 85 °C; (ii) 41b, Pd(dppf)Cl2, K3PO4 7H2O, toluene, 100 °C.