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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2017 May 19;25(15):3947–3963. doi: 10.1016/j.bmc.2017.05.032

Scheme 2.

Scheme 2

Synthesis of 7-(2-Aminopyridyl)- and 7-(2,4 Diaminopyrimidyl)indolesa

aReagents and conditions. (a) 41a or 41b, Pd(PPh3)4, Na2CO3 or Cs2CO3, dioxane/H2O, 100 °C. (b) Pd(PPh3)4, Na2CO3, dioxane/H2O, 100 °C.