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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2017 May 19;25(15):3947–3963. doi: 10.1016/j.bmc.2017.05.032

Table 1.

2,4-Diaminopyrimidine Inhibitors

graphic file with name nihms883163u2.jpg
Cmpd R1 X Y R2 R3
6a (CH2)3OMe O O - -
6b (CH2)3OMe O H,H - -
6c (CH2)3OMe CH2 H,H - -
6d (CH2)2NHCOMe CH2 H,H - -
7a (CH2)3OMe - - Me Me
7b (CH2)2NHCOMe - - Me Me
7c (CH2)3OMe - - Me graphic file with name nihms883163t1.jpg
7d (CH2)2NHCOMe - - Me graphic file with name nihms883163t1.jpg
7e (CH2)3CF3 - - Me graphic file with name nihms883163t1.jpg