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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2017 May 19;25(15):3947–3963. doi: 10.1016/j.bmc.2017.05.032

Table 5.

Comparison of benzoxazinones that were designed, synthesized, and tested.

graphic file with name nihms883163u5.jpg
Cmpd X R1 R2 R3 IC50 (μM) LE
7b N Et NH2 (CH2)2NHCOMe 0.147 0.33
32 CH Et Me (CH2)2NHCOMe 0.069 0.35
33 CH Et OMe (CH2)2NHCOMe 0.045 0.33
34 CH Et Me (CH2)3OMe 0.267 0.31
35 CH Et Me (CH2)2NHCO2Me 0.121 0.30