. Author manuscript; available in PMC: 2018 Aug 1.

Published in final edited form as: Bioorg Med Chem. 2017 May 19;25(15):3947–3963. doi: 10.1016/j.bmc.2017.05.032

Table 6.

Rat Pharmacokinetic Data.

Cmpd	t_1/2^a (h)	VD_ss^a (L/kg)	Cl^a (mL/kg min)	%F^b	AUC^b (ngh/mL)	C_max^b (ng/mL)
27	2.2	10	68	20	473	87
32	1.0	3.4	66	58	1810	529
33	2.0	5.4	56	39	1493	331

1 mg/kg iv dose.

10 mg/kg po dose. Compounds dosed as their HCl salts; vehicle = D5W.