Table 7.

Comparison of Some Key Metrics

Cmpd	Measured IC50 (μM)	Literature IC50 (μM)	MW	cLogP	LE	Relative LE cf. 7b	%F (rat)
1	0.003	0.0006	551	3.5	0.30a/0.32b	0.9	2.4
7b	0.147	0.020	385	2.8	0.33a/0.37b	1	ndc
7c	-	0.007	483	4.3	0.32	0.86	0.4
7d	-	0.001	496	3.3	0.34	0.91	8
rac-7e	-	0.141	521	5.0	0.25	0.68	12
(S)-7e	-	0.048	521	5.0	0.27	0.73	74
27	0.059	-	341	3.8	0.39	1.18	20
32	0.069	-	396	3.6	0.35	1.06	58
33	0.045	-	412	2.2	0.33	1.05	39

^aBased on measured IC₅₀.

^bBased on literature IC₅₀.

^cNot determined.