. Author manuscript; available in PMC: 2017 Aug 11.

Published in final edited form as: J Low Genit Tract Dis. 2012 Oct;16(4):471–479. doi: 10.1097/LGT.0b013e3182472947

Table 2.

HPV status and genotype distribution in invasive vulvar cancer and in situ vulvar cancer (VIN3) cases, based on registry classification

	Invasive (n=176)		In Situ (VIN3) (n=68)		P-value
	N	%	N	%	P-value

HPV positive	121	68.8	66	97.1	<.0001
HR-HPV^* positive	119	67.6	64	94.1	<.0001
Individual HPV genotypes^†
16	85	48.3	55	80.9
18	3	1.7	1	1.5
33	18	10.2	6	8.8
52	5	2.8	0	0.0
59	0	0.0	2	2.9
Multiple genotype, among all cases	11	6.3	4	5.9	1.00
Multiple genotypes, among HPV-positive samples	11	9.1	4	6.1	0.58

HR-HPV defined as types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68.

^†

The following additional genotypes were tested and identified in <2% of all cases: 6, 11, 26, 31, 35, 39, 40, 42, 43, 44, 45, 51, 53, 54, 55, 56, 58, 61, 62, 64, 66, 67, 68, 69, 70, 71, 72, 73, 74, 81, 82, 83, 84, IS39 and X.