Table 5.
Comparison between HPV-positive and HPV-negative invasive vulvar cancers*: associated VIN types and age at diagnosis
| Total | VIN Type | Age at Diagnosis (years) | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| Differentiated | Warty/Basaloid | Other/None | P-value | Median | Range | P-value | ||
| No. (%) | No. (%) | No. (%) | No. (%) | |||||
|
|
|
|
||||||
| Total | 148 (100.0) | 36 (24.3) | 74 (50.0) | 38 (25.7) | 70 | 35–98 | ||
| All Invasive Histology | 148 (100.0 | |||||||
| HPV-positive | 101 (68.2) | 16 (44.4) | 64 (86.5) | 21 (55.3) | <.0001 | 64 | 36–95 | 0.005 |
| HPV-negative | 47 (31.8) | 20 (55.6) | 10 (13.5) | 17 (44.7) | 75 | 35–98 | ||
| SCC: Keratinizing | 55 (37.2) | |||||||
| HPV-positive | 27 (49.1) | 14 (42.4) | 5 (83.3) | 8 (50.0) | 0.20 | 73 | 41–95 | 0.93 |
| HPV-negative | 28 (50.9) | 19 (57.6) | 1 (16.7) | 8 (50.0) | 73 | 35–98 | ||
| SCC: Non-keratinizing | 14 (10.2) | |||||||
| HPV-positive | 12 (85.7) | 2 (66.7) | 4 (100.0) | 6 (85.7) | 0.69 | 68 | 39–90 | 0.47 |
| HPV-negative | 2 (14.3) | 1 (33.3) | 0 | 1 (14.3) | 75 | 65–85 | ||
| SCC: Warty/Basaloid | 70 (46.0) | |||||||
| HPV-positive | 58 (82.9) | 0 | 55 (85.9) | 3 (50.0) | 0.06 | 59 | 36–88 | 0.001 |
| HPV-negative | 12 (17.1) | 0 | 9 (14.1) | 3 (50.0) | 81 | 64–91 | ||
| Other Histology | 9 (6.6) | |||||||
| HPV-positive | 4 (44.4) | 0 | 0 | 4 (44.4) | – | 76 | 58–81 | 0.61 |
| HPV-negative | 5 (55.6) | 0 | 0 | 5 (55.6) | 61 | 40–80 | ||
*
Restricted to 148 cases with invasive focus present on reviewed slide.