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Neutralization curves of MAb PGT145 against mutant pseudoviruses. Neutralization was performed using the TZM-bl assay, and the percent neutralization was calculated as detailed in Materials and Methods. The curves are colored according to the type of mutation: glycan deletion, lavender; gp120 core disruption, cyan; interprotomer disruption, pink; intraprotomer disruption, tan; CD4bs abrogation, green. The wild type is colored black.
