FIG 1.

Gag-protease-mediated viral replication capacities in HIV-infected mother-infant pairs. (A) Data from 31 mother-infant pairs (MIPs). (B) Data from the 31 MIPs in panel A and an additional 10 MIPs for which analyses were undertaken in a separate laboratory. Gag-protease NL4-3 recombinant viruses derived from the infants had significantly lower viral replication capacities than those of viruses their mothers (P < 0.0001 as determined by a paired t test). Replication capacity was assayed in GXR cells by using flow cytometry and normalized to the growth of the wild-type NL4-3 virus (replication capacity value of 1).