FIG 7.
Longitudinal course of changes observed during progression to AIDS in infant macaques infected with SIVmac251 at 3 to 4 months of age. (A) PVL in four infant macaques infected with SIVmac251 were plotted as well as the mean PVL of four infected adult macaques (dashed line). (B) BrdU incorporation was evaluated for monocyte turnover at 24 h. Blood monocyte turnover rates were measured every 4 to 6 weeks during the course of infection until progression to AIDS or at indicated time points (dagger). Mean monocyte turnover rates (i.e., percent BrdU+ CD14+ monocytes) of the four infected adults are shown for comparison (dashed line). (C) Statistical analysis of monocyte turnover rates in infant macaques was performed by Kruskal-Wallis test corrected for multiple comparisons using Dunn's posttest. *, P < 0.05. UN, preinfection; pi, postinfection. (D) Absolute counts of monocytes.