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. 2017 Sep;92(3):338–346. doi: 10.1124/mol.117.108472

Fig. 3.

Fig. 3.

Identification of pore-lining residues required for Kir7.1 inhibition by VU590. (A) Percent inhibition of Kir7.1-WT (solid green bar), Kir7.1-M125R (solid blue bar), and respective mutants (striped bars) by 10 μM VU590. (B) VU590 CRCs for Kir7.1-WT, Kir7.1-M125R, T153C, A150S, and E149Q-M125R mutants. Data were analyzed using one-way ANOVA with Bonferroni’s multiple comparison test and plotted as mean ± S.D. (n ≥ 5). *P < 0.05, statistically significantly different from the respective control backgrounds (Kir7.1-WT or Kir7.1-M125R); N.F., nonfunctional; N.S., non-significant.