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. 2017 Sep;92(3):338–346. doi: 10.1124/mol.117.108472

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Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

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Fig. 4. — Effect of mutations at position 153 on the sensitivity of Kir7.1 to VU590. (A) Mean ± S.D. percent inhibition of Kir7.1-WT (solid green bar), Kir7.1-M125R (solid blue bar) channels and mutants (striped bars) by 10 μM VU590. (B) VU590 CRC comparison of Kir7.1-WT, Kir7.1-M125R, T153C, and T153S mutants. *P < 0.05, statistically significantly different from the respective control background (Kir7.1-WT or Kir7.1-M125R). Data were analyzed using one-way ANOVA with Bonferroni’s multiple comparison test. ^@P < 0.05, statistically significantly different from T153C and T153V mutants, n ≥ 5.