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VU590 SAR against Kir1.1 (Lewis et al., 2009) and Kir7.1 (Wright et al., 2015).
| Structure (R) | Name (R) | Kir1.1 IC50 | Kir7.1 IC50 | Ratio (Kir1.1) | Ratio (Kir7.1) |
|---|---|---|---|---|---|
| μM | μM | μM | μM | ||
 |
4-NO2 | 0.29 | 4.9 | 1 | 1 |
 |
3-NO2 | 14.2 | 6.6 | 47 | 1.3 |
 |
2-NO2 | >100 | >100 | >344 | >20 |
 |
2,4-NO2 | >100 | 4.2 | >344 | 0.9 |
 |
4-SMe | 8.5 | 4.3 | 29 | 0.9 |
 |
2-Cl | 1.3 | >100 | 4.5 | >20 |
