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. 2017 May 24;4(8):544–552. doi: 10.1002/acn3.426

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© 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Expected values of placebo RR50 and MPC. Each grid location represents the average value (RR50 or MPC) in the placebo arm of 1000 trials with identical parameters. All trials used number of patients (N) = 900, percentage of patients that drop out (dropout) = 0, and minimum monthly seizure rate during baseline required for inclusion (min) = 4. The different grid locations represent different combinations of baseline weeks (B) and test weeks (T) values for the trial duration. RR50 and MPC were both correlated with B and inversely correlated with T. Note that the color scales differ in the MPC figure and the RR50 figure. The lowest values of RR50 correspond to the most negative values of MPC.