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. 2017 Jun 21;4(8):564–574. doi: 10.1002/acn3.431

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© 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Chronic administration of EVOO‐rich diet ameliorates behavioral impairments in 3xTg mice. Starting at 6 months of age, 3xTg mice were randomized to receive regular chow diet (CTR) or diet enriched with EVOO (EVOO) until they were 12‐month‐old. (A) Monthly body weight of CTR (n = 12) and EVOO (n = 10) mice from the beginning until the end of the study. (B) The same mice were tested in the Y‐maze paradigm for the number of entries and the percentage of alternation (*P < 0.05, **P < 0.01). (C) Percentage of freezing in the contextual and cued phase of the fear conditioning paradigm (CTR n = 11, EVOO, n = 10). (D) Mice were also assessed in the Morris water maze paradigm for the number of entries to the platform zone, the time spent in the platform zone, and the time spent in the NE zone (CTR n = 11, EVOO, n = 10) (*P < 0.05). Values represent mean ± SEM.