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. 2017 Jun 21;4(8):564–574. doi: 10.1002/acn3.431

Figure 2.

Figure 2

Chronic administration of EVOO‐rich diet decreases brain Aβ levels and deposition in 3xTg mice. (A,B) RIPA‐soluble (RIPA) and formic acid soluble (F.A.) Aβ1‐40 and Aβ1‐42 levels in brain cortex homogenates of 3xTg receiving EVOO (n = 8) or vehicle (CTR) (n = 8) (C) Representative images of brain sections of 3xTg mice receiving EVOO or vehicle (CTR) immunostained with 4G8 primary antibody (Scale bar 100 μm). (D) Quantification of the area occupied by Aβ immunoreactivity in brains of 3xTg mice receiving EVOO (n = 4) or vehicle (CTR) (n = 4) (*P < 0.05). E. Representative Western blots of APP, sAPP α, sAPP β, BACE1, ADAM10, APH1, Nicastrin, Pen2, PS1, ApoE, IDE, and CD10 in the brain cortex homogenates from 3xTg mice receiving EVOO (n = 4) or vehicle (CTR) (n = 4). (F) Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel (*P < 0.05). Values represent mean ± SEM.