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. 2017 Jun 21;4(8):564–574. doi: 10.1002/acn3.431

Figure 4.

Figure 4

Effect of chronic administration of EVOO‐rich diet on synaptic integrity and neuroinflammation. (A) Representative western blot analyses of synaptophysin (SYP) and postsynaptic density protein 95 (PSD95) in brain cortex homogenates of 3xTg mice treated with EVOO (n = 4) or vehicle (CTR) (n = 4). (B) Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel (*P < 0.05). (C) Representative images of brain sections from 3xTg mice receiving EVOO or vehicle (CTR) immunostained with SYP antibody. (D) Quantification of the integrated optical density (IOD) by the immunoreactivity to the same antibody shown in the previous panel (*P < 0.05). (E) Representative western blot analyses of GFAP and IBA1 in brain cortex homogenates of 3xTg mice treated with EVOO (n = 4) or vehicle (CTR) (n = 4). (F) Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel (*P < 0.05). (G) Representative images of brain sections from 3xTg mice receiving EVOO or vehicle (CTR) immunostained with IBA1 antibody. (H) Quantification of the integrated optical density (IOD) by the immunoreactivity to the same antibody shown in the previous panel (**P < 0.01). Values represent mean ± SEM.