Table 3.

Results of multivariable Cox analysis of predictors of survival and recurrence

	OS, HR (95% CI)	p value	HDFS, HR (95% CI)	p value
Full model
Maximal tumor size	1.02 (0.95–1.10)	0.515	—	—
Multiple metastases	—	—	1.44 (0.90–2.32)	0.131
Extrahepatic disease	2.19 (1.15–4.16)	0.036	2.25 (1.16–4.34)	0.016
Preoperative PVE	—		1.62 (0.86–3.04)	0.136
Neoadjuvant chemotherapy	1.83 (1.20–2.78)	0.005	—	—
Tumor fibrosis >40%	0.45 (0.21–0.98)	0.045	0.42 (0.17–1.05)	0.063
FLR texture signal	2.19 (1.09–4.40)	0.028	1.94 (1.02–3.69)	0.044
Tumor texture signal	2.08 (0.97–4.45)	0.081	2.2 (1.02–5.02)	0.045
Final model
Extrahepatic disease	2.25 (1.21–4.17)	0.010	2.39 (1.25–4.57)	0.008
Neoadjuvant chemotherapy	1.84 (1.21–2.80)	0.005	—	—
Tumor fibrosis >40%	0.46 (0.21–1.00)	0.049	0.45 (0.18–1.12)	0.086
FLR texture signal	2.15 (1.08– 4.29)	0.029	2.21 (1.21–4.03)	0.010
Tumor texture signal	2.35 (1.21–4.55)	0.013	2.09 (0.95–4.58)	0.066

OS overall survival, HDFS hepatic disease-free survival, PVE portal vein embolization, FLR future liver remnant