Figure 3.
The effect of serum concentration on in vitro potency. The antiproliferative and cytotoxic potencies of paclitaxel, taccalonolide AF and taccalonolide AJ were evaluated in the presence of 0.1% (green), 1% (red) or 10% (blue) serum. A dashed line at 0% cell growth denotes the density of cells at the time of drug addition, such that values above and below this line indicate antiproliferative and cytotoxic activities, respectively. Individual points represent the mean ± SEM for 3 independent experiments with each concentration tested in triplicate.