Skip to main content
. Author manuscript; available in PMC: 2017 Oct 19.
Published in final edited form as: Neuron. 2016 Sep 29;92(2):461–478. doi: 10.1016/j.neuron.2016.09.014

Figure 7. Physical coupling of TRPV1 and CaV1.2 channels by AKAP150 in sensory neurons.

Figure 7

(A) Shown are triple-color STORM images displaying AKAP150-mediated multi-channel complexes containing CaV1.2 and TRPV1 channels from NG sensory neurons isolated from WT mice. (B) Shown are dual-color STORM images showing discrete channel complexes containing CaV1.2, or TRPV1 channels from NG neurons isolated from AKAP150 KO mice. (C–D) Plotted are distributions of STORM nearest-neighbor distances for AKAP150/TRPV1, CaV1.2/TRPV1, and AKAP150/CaV1.2 from WT neurons (C) or CaV1.2 and TRPV1 from AKAP150 KO neurons (D), indicating intimate association of CaV1.2 and TRPV1 channels and AKAP150, in cells from WT, but not AKAP150, mice. n=4 and 5 cells.