Table 2.
Minimal Inhibitory Concentrations and Potentiating Activities of NSC 60339 and NSC 33353 in Gram-Negative Bacteriaa
| strain | MIC, μM | MPC4 NOV, μM | MPC4 ERY, μM | MPC4 LEVO, μM | ||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
|||||
| 60339 | 33353 | 60339 | 33353 | 60339 | 33353 | 60339 | 33353 | |
| E. coli BW25113 | >200 | 200 | 100 | 25 | 50 | 25 | 50 | 50 |
| P. aeruginosa PAO1 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
| A. baumannii ATCC 17798 | >100 | >100 | >100 | 6.25 | >100 | 50 | >100 | >100 |
| E. cloacae ATCC 13047 | >100 | >100 | >100 | 25 | >100 | 25 | >100 | >100 |
| K. pneumoniae ATCC 13883 | >100 | >100 | >100 | 12.5 | >100 | 12.5 | >100 | 25 |
a
NOV, novobiocin; ERY, erythromycin, LEVO, levofloxacin.