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Potentiation of Antibiotic Activities and Binding to AcrA by NSC 60339 Analogues
| compound | MIC WT-Pore, μM | MPC4 NOV, μM | MPC4 ERY, μM | binding to AcrA |
|---|---|---|---|---|
| SLU-PP-258 (NSC 60339) | 100–200 | 25 | nda | yes |
| SLU-PP-227 | 100–200 | 50 | 25 | weak |
| SLU-PP 187 | 200 | 25 | 25 | yes |
| SLU-PP-192 | 100–200 | 50 | 12.5 | nd |
| SLU-PP-228 | 50 | NAa | NA | no |
| SLU-PP-103 | >400 | >200 | NA | no |
| SLU-PP-194 (NSC 33353) | 100 | 1.56–3.125 | nd | yes |
| NSC 23925 | 400 | 100 | 50 | weak |
| vacquinol-1 | 100 | 25 | NA | weak |
NA, no activity; nd, no data.
