Experimental data, unimodal distribution: blue, reference signal; red, noisy signal; black, WavPDS denoised signal. The experimental signal was generated from T4 Lysozyme spin-labeled at mutant 44C/135C with 63 µM concentration at acquisition times 952, 112, and 14 min (section 2.E). (A) Comparison of noisy and denoised signals. (B) Comparison of reference signal with denoised signals after applying WavPDS. (C) Distance distributions from noisy, denoised, and reference signals. The denoised signal at 952 min was used as the reference.