Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Glucotoxic conditions promote inactivation of protein prenyltransferases leading to inhibition of prenylation of Rac1. Unprenylated Rac1 undergoes sustained activation, which may, in part, be due to its weak association with GDI as well as activation by at least 2 GEFs [Tiam1 and Vav2]. Unprenylated, but active Rac1, translocates to the nucleus and promotes activation of proapototic stress kinases/factors leading to β-cell dysfunction and apoptosis.
