Table 4.

Criteria of toxicity effect based on changes in cell morphology [12].

Grade	Toxicity	Cell Morphology
0	lack	Discrete intracytoplasmic granules, no evidence of cell lysis, lack of inhibition of cell growth
1	weak	No more than 20% of rounded, shrunk cells, separating from the substrate without densities of cytoplasm, individual cells disrupted
2	moderate	No more than 50% of rounded cells, no evidence of granules, vast cell lysis and empty spaces between cells
3	average	No more than 70% of rounded cells, cells underwent lysis
4	strong	Almost completely or completely damaged cell culture