Table 2.
Univariate analysis of factors affect post-recurrence survival.
| Variables | Median post-recurrence survival (months) | χ2 | P value |
|---|---|---|---|
| Age at surgery (years) | |||
| <65 | 17 | 6.702 | 0.010 |
| ≥65 | 11 | ||
| Gender | |||
| Male | 15 | 1.842 | 0.175 |
| Female | 22 | ||
| Preoperative smoking status | |||
| Non-/Light smoker | 15 | 0.856 | 0.355 |
| Heavy smoker | 17 | ||
| Preoperative CRP | |||
| ≤1.0 g/dl | 16 | 0.126 | 0.723 |
| >1.0 g/dl | 17 | ||
| CRP at recurrence | |||
| ≤1.0 g/dl | 19 | 4.931 | 0.026 |
| >1.0 g/dl | 13 | ||
| Albumin at recurrence | |||
| ≥3.5 g/dl | 17 | 7.517 | 0.006 |
| <3.5 g/dl | 5 | ||
| Preoperative mGPS | |||
| 0 | 16 | 5.492 | 0.064 |
| 1 | 19 | ||
| 2 | 8 | ||
| mGPS at recurrence | |||
| 0 | 19 | 10.711 | 0.005 |
| 1 | 14 | ||
| 2 | 4 | ||
| Histological type | |||
| A or AS | 17 | 29.581 | <0.001 |
| SCC | 16 | ||
| LCLC/Sarcoma | 4 | ||
| Pathological stage | |||
| IA to IIB | 19 | 2.657 | 0.103 |
| IIIA/IIIB | 14 | ||
| Adjuvant treatment | |||
| Chemotherapy | 15 | 2.835 | 0.418 |
| PORT | 25 | ||
| Chemoradiotherapy | 15 | ||
| None | 15 | ||
| Disease-free interval (months) | |||
| <12 | 14 | 3.556 | 0.059 |
| ≥12 | 19 | ||
| Recurrent site | |||
| Local (intrathoracic) | 17 | 1.177 | 0.555 |
| Distant (extrathoracic) | 15 | ||
| Both | 22 | ||
| No. of recurrent foci | |||
| Single | 18 | 0.067 | 0.796 |
| Multiple | 11 | ||
A – adenocarcinoma; AS – adenosquamous carcinoma; SCC – squamous cell carcinoma; LSLC – large cell lung cancer; PORT – post operation radiotherapy; Light smoker – smoking index ≤40 pack-years; Heavy smoker – smoking index >40 pack-years. P values <0.05 in bold.