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View full-text article in PMC

. Author manuscript; available in PMC: 2017 Aug 11.

Published in final edited form as: Genes Brain Behav. 2017 Jan 17;16(4):449–461. doi: 10.1111/gbb.12362

Table 1.

Experimental timelines

A. The 4-day alcohol drinking-in-the-dark (DID) model and alcohol preference (alcohol vs. water) on day 5
Day 1	Day 2	Day 3	Day 4	Day 5
4-h alcohol	4-h alcohol	4-h alcohol	4-h alcohol	4-h alcohol vs water

B. The 3-week chronic intermittent access (IA) drinking model (15% alcohol vs. water) every other day with mu- (naltrexone) or kappa- (nor-BNI) opioid antagonist or morphine.
Week 1	Week 2	Week 3	Week 4
24-h alcohol vs water	24-h alcohol vs water	24-h alcohol vs water	Naltrexone, nor-BNI, morphine

C. The alcohol deprivation effect (ADE) model after 1-week abstinence from a 3-week chronic intermittent access (IA) drinking (15% alcohol vs. water)
Week 1	Week 2	Week 3	Week 4	Week 5
24-h alcohol vs water	24-h alcohol vs water	24-h alcohol vs water Baseline (BL)	Alcohol abstinence	ADE, alcohol vs water Post-abstinence (P)