Table 2. Genotype differences in alcohol (7.5, 15 or 30%) preference after 4 days of drinking-in-the-dark (DID) in male (A) and female (B) nPE mice.
On the test day, both alcohol (7.5%, 15% or 30% concentration) and water were presented 3 hours after the beginning of dark cycle, and alcohol and water intake values were recorded after 4 hours of alcohol access in the nPE+/+ and nPE−/− mice. Genotype difference: *p<0.05 vs. nPE+/+ by Student’s t-tests.
A. Males | ||||||
---|---|---|---|---|---|---|
Genotype | 7.5% alcohol | 15% alcohol | 30% alcohol | |||
nPE+/+ (n=5) |
nPE−/− (n=5) |
nPE+/+ (n=9) |
nPE−/− (n=8) |
nPE+/+ (n=5) |
nPE−/− (n=5) |
|
Alcohol Preference | 0.83±0.04 | 0.60±0.03* | 0.67±0.08 | 0.42±0.04* | 0.50±0.04 | 0.51±0.04 |
B. Females | ||||||
---|---|---|---|---|---|---|
Genotype | 7.5% alcohol | 15% alcohol | 30% alcohol | |||
nPE+/+ (n=5) |
nPE−/− (n=5) |
nPE+/+ (n=6) |
nPE−/− (n=7) |
nPE+/+ (n=6) |
nPE−/− (n=6) |
|
Alcohol Preference | 0.85±0.03 | 0.54±0.02* | 0.61±0.06 | 0.24±0.07* | 0.55±0.07 | 0.59±0.02 |