Table 1.
Expression of mannose receptor, LSECtin, langerin, and DC-SIGN family receptors correlates with dextran uptake capacity
| Organ | Receptor expression | Dextran uptake |
|---|---|---|
| Liver | 1) MR: Kupffer cells, LSEC (16) | 1) Dextran uptake is present in Kupffer cells (39) and in LSEC (40) |
| 2) L-SIGN, LSECtin: LSEC (31) | 2) Dextran uptake is present in LSEC (40); dextran uptake is present in liver DCs (41) | |
| Spleen | 1) MR: splenic macrophages, endothelial cells (16) | 1) Dextran uptake is present in phagocytes (39) and can be presumed according to dextran uptake along capillaries in endothelial cells (42) |
| 2) SIGN-R1: spleen macrophages (35) DC-SIGN: spleen DCs (26) |
2) SIGN-R1-dependent dextran uptake is present in spleen macrophages (35); dextran uptake is present in spleen phagocytes (39) and in spleen DCs (41) | |
| Lung | 1) MR: alveolar macrophages (16) | 1, 2) Dextran uptake is present in alveolar macrophages (43) |
| 2) DC-SIGN: alveolar macrophages (25) | ||
| Kidney | MR: macrophages, glomerular mesangial cells (16) | Dextran uptake is present in phagocytes (39) and in mesangial cells (44) |
| Heart muscles | MR: macrophages (16) | Dextran uptake is present in phagocytes (39) |
| Brain | MR: retinal microglia cells (45) | Dextran uptake is present (45) |
| Skin | MR: dermal microvascular endothelial cells (46) | Dextran uptake is present (46) |
| Lymphatic system | 1) MR: endothelial cells of the lymph ducts (47) | 1) Dextran uptake (or at least binding) seems to be present in lymphatic endothelial cells due to dextran use in visualization of lymph vessels (49–51) |
| 2) L-SIGN and LSECtin: endothelial cells of the lymph ducts and lymph nodes (31, 48); LSECtin: peripheral blood and thymic DCs (31) | 2) Dextran uptake or binding seems to be present in lymphatic endothelial cells due to dextran use in visualization of lymph vessels (49, 51) | |
| APC | 1) MR: APCs in skin, muscles, salivary gland, thyroid, pancreas (52) | 1, 2, 3) Dextran uptake is present in human immature MDDCs and Langerhans cells (53), plasmacytoid DCs (54), activated B cells (55) |
| 2) DC-SIGN: human immature MDDCs, mucosal DCs, immature DCs on periphery (skin, tonsils), and mature DCs in lymphoid organs (26); plasmacytoid DC precursors (25); activated B cells (23) | ||
| 3) Langerin: Langerhans cells |
APC, antigen-presenting cell; DC-SIGN, dendritic cell–specific intercellular adhesion molecule (ICAM) 3-grabbing nonintegrin; L-SIGN, liver/lymph node-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin; LSEC, liver sinusoidal endothelial cell; MDDC, monocyte-derived dendritic cell; MR, mannose receptor.