Table 2.

Results of multivariable linear regression SUV_kg average for blood-pool, liver, and spleen along with Ln(SUVkg) multivariable linear regression. Blood-pool measurements had the least degree of variability, as indicated by the lowest root mean square (MSE), while spleen had the highest degree of variability. Additionally, blood glucose effect (slope) was not different (p < 0.0001) between blood-pool and liver. The slope for blood glucose effect on the brain (ln transformed data) was larger and negative compared to that for the blood or liver. Note time from FDG injection to imaging time had no effect on the results.

	Estimate	Std Error	P value	Root MSE
Ln(Brain Ave. SUVkg)
Intercept (Ln SUVkg)	2.2363	0.1095	< 0.0001
Glucose (Ln SUVkg/glucose)	−0.0067	0.0004	< 0.0001
BMI	0.0149	0.0025	< 0.0001
Injections to Imaging Time	−0.0003	0.0013	0.8262
Diabetes (Ref = No)	−0.0739	0.0324	0.0232
Tumor Type (Ref = LUNG)
LYMPH	−0.0727	0.0344	0.0356
OTHER	0.0127	0.0334	0.703
SCCA	−0.0549	0.0386	0.1559
Blood Ave. SUVkg				0.2991
Intercept (SUVkg)	1.1933	0.1299	< 0.0001
Glucose (SUVkg/glucose)	0.0044	0.0005	< 0.0001
BMI	0.0196	0.0031	< 0.0001
Injections to Imaging Time	−0.0024	0.0015	0.1054
Diabetes (Ref = No)	−0.1655	0.0399	< 0.0001
Tumor Type (Ref = LUNG)
LYMPH	0.0047	0.0406	0.9069
OTHER	0.0942	0.0405	0.0206
SCCA	0.0972	0.0476	0.0419
Liver Ave. SUVkg				0.3688
Intercept (SUVkg)	1.2783	0.1602	< 0.0001
Glucose (SUVkg/glucose)	0.0047	0.0007	< 0.0001
BMI	0.0328	0.0039	< 0.0001
Injections to Imaging Time	−0.0011	0.0018	0.5417
Diabetes (Ref = No)	−0.2345	0.0493	< 0.0001
Tumor Type (Ref = LUNG)
LYMPH	0.0488	0.05	0.3304
OTHER	0.1212	0.0499	0.0157
SCCA	0.1501	0.0587	0.011
Spleen Ave. SUVkg				0.3887
Intercept (SUVkg)	1.1509	0.1689	< 0.0001
Glucose (SUVkg/glucose)	0.001	0.0007	0.1553
BMI	0.023	0.0041	< 0.0001
Injections to Imaging Time	0.0048	0.0019	0.0129
Diabetes (Ref = No)	−0.1268	0.0519	0.0151
Tumor Type (Ref = LUNG)
LYMPH	0.0779	0.0527	0.1405
OTHER	0.0274	0.0526	0.6027
SCCA	−0.067	0.0619	0.2797