(A) Human heme oxygenase 2-Human adiponectin complex. Residues 238–246 (TGFLLYHDT) from adiponectin and 235–247 (NELDQAGSTLARE) from HO-2 are involved in the interaction. (B) Growth properties of a representative two-hybrid clone (rows 1,2) and a negative control clone (rows 3,4). Suspensions of overnight cultures, were serially (1:10) diluted in saline and spotted onto M9-based selective agar plates. C: Chloramphenicol; T: Tetracycline; 3AT: 3-Amino-1,2,4-triazole; S: Streptomycin.